Actionable Tissue Intelligence

for Drug Development

Nucleai helps biopharma answer two critical questions: why does a therapy work, and which patients will benefit?

Our AI-driven, expert-led approach combines multimodal tissue analysis with clinical outcomes linkage and traceable outputs, turning complex tissue biology into actionable intelligence.

What Tissue Intelligence Means

Tissue intelligence transforms the information contained in tissue into structured, interpretable evidence connected to biological and clinical questions. Rather than reducing a sample to a single marker or score, it examines how cells, proteins, and tissue structures are organized, how those patterns vary across patients, and how they relate to therapeutic response and clinical outcomes.
Nucleai delivers it as expert-led analysis: an integrated team of pathologists, biologists, data scientists, and AI experts adapts our models to each program's data and delivers interpreted tissue intelligence, not standalone software.

Multimodal by Design

Integrate H&E, IHC, multiplex imaging, and spatial transcriptomics.

AI-Powered Tissue Analysis

Advanced models extract image features in greater depth to reveal spatial context.

Linked to Clinical Outcomes

Establish which features explain response, resistance, survival.

Traceable & Explainable

Trace every finding back to the tissue image it came from.

From First Signal to Clinical Trial Deployment

We work with biopharma sponsors wherever tissue biology is central to a program decision, across oncology, immunology, metabolic disease and beyond, and including drug modalities such as ADCs and multispecifics.
Our work supports translational medicine, clinical biomarker, and translational pathology teams. Additionally we collaborate with translational researchers and spatial biology platforms to turn spatial biology data into actionable and scalable insights.
Translational Research

For discovery and translational research: from early signal and mechanistic understanding, to biomarker discovery and threshold-setting, to features tested and validated against clinical outcomes.

Clinical Development & Companion Diagnostics

For patient selection in trials and companion diagnostic development: a validated spatial biomarker built into a deployable scoring algorithm under design controls, running inside the trial workflow your sites already use.

Inside the Platform

A complete, configurable platform to turn complex tissue biology into structured, reproducible evidence.

Platform Overview

One platform to map tissue across imaging modalities, and link to outcomes.

Capabilities

From raw image to actionable intelligence, in one configurable pipeline.

Data and Modalities

A dedicated analytical approach for each data type, co-registered into one dataset per patient.

Trusted by Leading Biopharma and Research Partners

clinical trials
30 +
indications
10 +
of the top 20 biopharma companies
12 +

Data and Institutional Partners

Investors

Certified to Quality & IT Standards

Nucleai's medical device software is designed, developed, and deployed under a quality management system certified to ISO 13485:2016, and its information security management system is certified to ISO/IEC 27001:2022, by IQC.
Ready to Advance your Program?

Turn Your Tissue Data into Actionable Intelligence

Discover how Nucleai can help you uncover the biological evidence behind therapeutic response and support your drug development decisions.